Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols.
نویسندگان
چکیده
The asymmetric synthesis of tetrahydropyridin-2-ols from enals and enaminones is described. The organocatalytic domino reaction involves a Michael addition-hemiaminalization sequence using the Jørgensen-Hayashi catalyst. Dehydration or oxidation leads to the corresponding 1,4-dihydro-pyridines or 3,4-dihydropyridin-2-ones in a one-pot fashion.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 80 شماره
صفحات -
تاریخ انتشار 2012